Metallic derivative or compound of the active principle of the suprarenal glands.



NEED "STATES PATENT oFricE.

JOSEPH I1. TURNER, OF PHILADELPHIA, PEN-N HUI-FORD GOMPANY, OF PHILADEISPHIA,

PENNSYLVANIA.

PENNSYLVANIA, A CORPORATION METALLIC- DERIVATIVE on common!) OF THE Aorrvn PRINCIPLE or THE surna- RENALGLANDS.

Tytlfii-Jldfif No Drawing.

To all whom it may concern:

Be it known that I, JOSEPH L. TURN'ER, a subject of the Emperor of Russia, having declared my intention of becoming a c1t1- zen of the United States, residing in Philadelphia, Pennsylvania, have invented a cer tain Improved Metallic Derivative or Compound of the Active Principle of the prarenal Glands,

of which the following is a specification. I

The object of this invention is a metallic derivative or. compound of the active principle of'the suprarenal glands, which shall possess the active blood-pressureraising, astringent and hemostatic characteris'tics" and properties of said glands in a concentrated form, and from which substantially colorless solutions of-commercially useful strengths may be prepared. Such a derivative or compound of the glands I prepare as follows: Fifty pounds of suprarenal lands are disintegrated, and

are mixed wit which one ounce acid, and two ounces of zinc dust have been added. This mixture is then brought up gradually to the temperature of 75 C. and kept at this temperature for say fifteen minutes. The glands are then strained and five gallons of water to pressed ofi, and the residue is treated with an additional five allons of water in the same manner, an ,again strained and pressed oil. The extracts thus obtained are 7 mixed, and the mixture cooled and filtered.

- form of a solution,

The filtrate is now evaporated at low temperature oacuo to about 600 cc. and poured into 6000 c.c. of 95 per cent. ethyl alcohol, the mixture being constantly stirred during pouring. The precipitate thus formed is filtered oil and to the filtrate is added 350 grams of powdered alum (potassium aluminum sulfate) either dry or 1n the and this mixture is constantly shaken for from 2 to 3 hours. The liquid is then again filtered and the slightly acid filtrate neutralized by the addition of ammonia; thereupon, a precipitate of an aluminum compound of the active principle of the suprarenal glands separates out, and after standing-for an hour in a cool place is filtered off, washed with alcoholand ether,

Specification of Letters ream. Application filed January 29, 19.12. Serial No. 674,032.

ordinary temperatures,

of concentrated sulfuric obtained is a yellowish white amorphous poW-Cl'enpossessing the physiological characteristics of the active principle of the suprarenal gland in concentrated form, but difi'ering from that active principle as heretofore isolated, in the particulars among others of being a metallic derivative, in being amorphous, readily soluble, in water at and having no definite melting point.- p

I do notin this application claim the herein described process, that being claimed in my allowed application for patent Serial Number 643,048 which has matured into Patent 1,016,185.

From the above described metallic derivative or compound of the active commercial use, as, for example, from 1-50o (0.2%) to 1 10,000 (0.01%) may be made by dissolving a given quantit of the material in Water, to which is a deed SYEVANIA, ASSIGNOR TO THE H. K.

Patented May 6, 19153. I

rinciple of the suprarenal gland, commerclally stable solutions of various desired strengths for that amount of hydro-chloric, boric, or other suitable acid calculated in accordance with the well-known ordinary stoicheiometric proportions, to be required to form a salt with that quantity of the metallic derivative, and adding to this solution a small quantity of a preservative such as, for example, acetonechloroform, sulfites, or the like.

Other water-soluble, and alcohol-insoluble salts of metals may be employed, for the obtaining of metallic derivatives or compounds, from which-substantially colorless solutions possessing the active blood-pressure-raising, astringent and hemostatic characteristics and properties of the suprarenal glands in a concentrated form may be prepared, such salts, for. example, as 'zinc sul ate, or magnesium sulfate. I wish it to be understood, therefore, that I do not limit my claims isave where so expressed) to an aluminum derivative or compound, nor to a metallic derivative or compound when obtained by the particular above described process.

The phrase substantially colorless soluv 100 tions as used in'this description and in the accom anying claims is to be understood as referring to solutions sufiiciently dilute for medical use, yet of suflicient strength to be commercially useful, as, for example, solutions varying in strength from 1-500 (0.2%) or thereabout, to 1-10,000 (0.01%) or thereabout and as including solutions which, While not absolutely colorless, are so nearly so, as not to be objectionable, by'reason of color, to users or venders of this class of remedies.

Claims 1. A metallic derivative or compound of the active principle of the suprarenal gland,

being a compound with said principle of the metallic element of'a water-sqlublelbut aloehol-insoluble salt a l f empound possessing, blood -raising, astringent and and properties of said glands, being readily hemostatic characteristics soluble in water, and capable of forming therein substantially colorless solutions of commercially useful strength.

2. The within described aluminum derivaordinary temperatures, and forming therein a substantially colorless solution.

In testimony whereof, I have signed my name to this specification, in the presence of two subscribing Witnesses.

JOSEPH L. TURNER.

Witnesses: 1

WILLIAM E. BRADLEY J 0s. H. KLEIN. 

